Movement patterns in rheumatic and musculoskeletal diseases

Recruiting

Conditions: M00-M99
Diseases of the musculoskeletal system and connective tissue

Registration Number: DRKS00033076

Lead Sponsor: niversitätsklinikum Erlangen, Medizinische Klinik 3 - Rheumatologie & Immunologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 800

Inclusion Criteria

Patients with a diagnosis of inflammatory rheumatic diseases (e.g. rheumatoid arthritis, spondyloarthritis (psoriatic arthritis, axial spondyloarthritis), myositis, scleroderma, vasculitis)
- Patients with an increased risk of developing an inflammatory rheumatic disease (psoriasis, anti-CCP positive patients (preRA))
- Patients with degenerative joint diseases (osteoarthritis of the knee) and
- healthy controls
- Patients must be able to walk a specified distance (4 x 10 metres) or walking time (up to 2 minutes) independently, without assistance.
- Age = 18 years
- Written consent to study participation and data protection

Exclusion Criteria

- surgical interventions or osteoarthritis of the lower limbs, spinal disc herniation or other factors that could influence gait
- Patients who are dependent on walking aids, wheelchairs or assistance when walking.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Space-time parameters of walking (double step duration, double step length, cadence, number of steps, gait speed), ankle, knee and hip joint angles, walking distance (2 min walk test), physical activity (IPAQ), diagnosis

Secondary Outcome Measures

Name	Time	Method
Association of primary outcome measures with clinical routine and corresponding rheumatic disease (e.g. DAS-28, PSAID, RAID, MASES, BASMI, BASDAI, routine laboratory parameters, joint status) as well as patient well-being (e.g. SF-36, HAQ), physical activity-related health literacy (PAHCO), chronic pain of neuropathic origin (PainDetect) and fear of pain (TSK).<br><br>In addition, past fractures, smoking status, menopausal status in women, medical history and dietary habits that could affect bone/cartilage health (injuries, medications, supplements).