Oxidative Stress is Associated with Impaired Cardiac Autonomic Control and Lung Function in COPD Patients

Not Applicable

Completed

• Conditions: COPD patients with no exacerbationNon- COPD; oxidative stress; smoking male healthy controls; heart rate variability; lung function

• Registration Number: TCTR20160607001
• Lead Sponsor: Faculty of Medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-12-28
• Study Start: 2016-06-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

Group 1. The diagnosis of COPD and its severity were determined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015 guidelines [1]. COPD patients with GOLD stage I (FEV1 ≥ 80% predicted), II (50%  FEV1 < 80% predicted), III (30%  FEV1 < 50% predicted), and IV (FEV1 < 30% predicted) numbered 14, 19, 16, and 1 patients, respectively. None of the COPD patients had COPD exacerbation within the three months prior to the start of the study.

Group 2. non-smoking healthy male controls

Exclusion Criteria

Subjects meeting any of the following criteria were excluded from the study: history of cardiac arrhythmias or potential ECG alterations, history consistent with heart disease, diabetes mellitus, hypertension or other concomitant respiratory diseases, central or peripheral nervous system diseases, and electrolyte imbalance.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
oxidative stress 12/01/2015 to 15/02/2016 MDA,cardiac autonomic control 12/01/2015 to 15/02/2016 HRV,lung function 12/01/2015 to 15/02/2016 FVC, FEV1, MEF, and PEF

Secondary Outcome Measures

Name	Time	Method
lung function 12/01/2015 to 15/02/2016 FVC, FEV1, MEF, and PEF