Postoperative Cognitive Function and EEG
- Conditions
- Postoperative Cognitive DysfunctionAgingEEG With Periodic Abnormalities
- Interventions
- Other: EEG(Electroencephalogram) change
- Registration Number
- NCT04219033
- Lead Sponsor
- Air Force Military Medical University, China
- Brief Summary
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of EEG parameters related to postoperative cognitive dysfunction
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1250
- aged 65 and above
- non-cardiac surgery under general anesthesia;
- American Society of Anesthesiology(ASA) classification I- II
- Patients aged 18-40 years old are set as background
- patients with central nervous system diseases and mental diseases
- preoperative minimal mental status examination(MMSE) score<24;
- ASA status III or higher
- those who have received less than 5 years of education since entering primary school; 4) history of sedatives or antidepressants use; 5) existed or anticipated alcohol or drug abuse(over 40°c and over 100ml per day for the past 3 months); 6) history of surgery within the previous year; 7) those with severe visual or hearing impairment; 8) those participated in other clinical studies within last 3 months;
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description with postoperative cognitive dysfunction EEG(Electroencephalogram) change - without postoperative dysfunction EEG(Electroencephalogram) change -
- Primary Outcome Measures
Name Time Method The difference of delta wave miss rate between patients with or without cognitive dysfunction by 1 day after surgery from end of surgery to 1 day after surgery The difference (OR) between the miss rate of delta wave in patients with and without cognitive function change 1 day after operation.
The difference of spindle miss rate between patients with or without cognitive dysfunction by 1day after surgery from end of surgery to 1 day after surgery The difference (OR) between the miss rate of spindle in patients with and without cognitive function change 1 day after operation.
- Secondary Outcome Measures
Name Time Method correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 3 days after surgery from end of surgery to 3 days after surgery correlation of burst suppression rate and incidence of postoperative cognitive dysfunction by 1 day after surgery from end of surgery to 1 day after surgery The difference of delta wave miss rate between patients with or without cognitive dysfunction by 3 days after surgery from end of surgery to 3 day after surgery The difference of spindle miss rate between patients with or without cognitive dysfunction by 3 days after surgery from end of surgery to 3 days after surgery correlation of spindle miss rate and incidence of death by 30 days after surgery from end of surgery to 30 days after surgery The difference of burst suppression rate between patients with or without cognitive dysfunction by 3 days after surgery from end of surgery to 3 days after surgery correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 1 day after surgery from end of surgery to 1 day after surgery correlation of spindle miss rate and incidence of postoperative cognitive dysfunction by 1d after surgery from end of surgery to 1d after surgery correlation of spindle miss rate and incidence of postoperative cognitive dysfunction by 3 days after surgery from end of surgery to 3 days after surgery correlation of burst suppression rate and incidence of postoperative cognitive dysfunction by 3 days after surgery from end of surgery to 3 days after surgery correlation of burst suppression rate and incidence of death by 30 days after surgery from end of surgery to 30 days after surgery correlation of delta wave miss rate and incidence of death by 30 days after surgery from end of surgery to 30 days after surgery
Trial Locations
- Locations (18)
Suzhou First People's Hospital
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital Nanchang University
🇨🇳Nanchang, Jiangxi, China
General Hospital of Northern Theater Command
🇨🇳Shenyang, Liaoning, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
Qinhai Provincial People's Hospital
🇨🇳Xining, Qinghai, China
The Second Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Shanxi Bethune Hospital
🇨🇳Taiyuan, Shanxi, China
Second Hospital of Shanxi Medical University
🇨🇳Taiyuan, Shanxi, China
China-Japan Friendship Hospital
🇨🇳Beijing, China
Xinqiao Hospital of Army Medical University
🇨🇳Chongqing, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
People's Hospital of Jiangsu
🇨🇳Nanjing, China
Zhongnan Hospital of Wuhan University
🇨🇳Wuhan, China
Weinan Central Hospital
🇨🇳Weinan, China
People's Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
People's Hospital of Zhanjiang
🇨🇳Zhanjiang, China
Traditional Chinese Medicine Hospital of Henan
🇨🇳Zhengzhou, China
First Hospital of Shanxi Medical University
🇨🇳Taiyuan, Shanxi, China