Plasma metabolomics and proteomics profiling in subjects with low-grade inflammation given a dietary lipid challenge
- Conditions
- Endocrine, nutritional and metabolic disease
- Registration Number
- KCT0001145
- Lead Sponsor
- Ewha Womans University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
1) Subject who voluntarily agrees to participate and sign in informed consent form
2) Subject who can participate all visits after rondomization
3) Age: 20 years = Age = 65 years
4) BMI (Body Mass Index): = 25 kg/m2
5) CRP (C-reactive protein): 1.0 - 8.1 mg/L
1) Continuous consumption of dietary supplement or oriental medicine or drug that affect inflammation, antioxidative capacity and lipid metabolism within 4 weeks before the first visit
2)Current consumption of anticoagulant within 4 weeks before the first visit
3)Following diseases :
Chronic inflammatory disease, diabetes, liver dysfunction, renal dysfunction, cardiovascular diseases (hypertension, stroke, etc.), thyroid diseases, etc.
4)Decrease of more than 4 kg body weight within 4 weeks before the first visit
(weight-loss therapy)
5)Excessive exercise (= 7 hours / week)
6)Smoking = 10 cigarettes / day
7)Alcohol consumption 140g / week
8) Subjects with hypersensitivity to test materials
9) Participation in other human study within 4 weeks before the first visit
10) Pregnant or lactating women
11) Any condition that the principal investigator believes may put the subjects at undue risk
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Markers of Inflammation
- Secondary Outcome Measures
Name Time Method Antioxidative markers;Markers of blood glucose ;Blood lipid profiles