Problem adaptation therapy for depression in dementia (PATHFINDER)

Not Applicable

Suspended

• Conditions: Depression in Alzheimer's disease; Nervous System Diseases; Alzheimer disease

• Registration Number: ISRCTN11185706
• Lead Sponsor: OCLOR

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-31
• Last Update Posted: 5 August 2022
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 336

Inclusion Criteria

1. Diagnosis of probable AD or mixed AD and vascular dementia using NIA-AA criteria
2. Mild to moderate dementia severity, defined by an SMMSE score >10
3. Clinically significant depression, defined by score of 8+ on the Cornell Scale for Depression in Dementia
4. Aged >50 years
5. Sufficiently fluent in English to engage with the PATH intervention
6. Identified family carer who spends >1 hour per day on at least 3 days per week with participant and agrees to act as co-therapist for intervention

Exclusion Criteria

1. Diagnosis of rarer dementias, including dementia with Lewy bodies, Parkinson’s disease dementia and frontotemporal dementia
2. Initiation of prescription or change in dose of antidepressant or other psychotropic medication in previous 4 weeks or plan to change treatment during the next 12 weeks
3. Those currently engaged in formal psychological therapy
4. Those requiring treatment for a severe psychiatric disorder such as schizophrenia or bipolar disorder
5. Are severely depressed and expressing suicidal ideation with active plans/suicidal behaviours and intent, as other forms of treatment and support would be indicated

Study & Design

• Study Type: Interventional
• Study Design: Not specified