A Study: Comparison between Positive Rates of Autologous Serum Skin Test and Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria

Not Applicable

Recruiting

• Conditions: Chronic spontaneous urticaria; Autologous serum skin test; ASST; Autologous plasma skin test; APST; Basophil histamine release assay; BHRA; AntiFcERIa autoantibody; CSU; Autoimmune chronic spontaneou

• Registration Number: TCTR20140822001
• Lead Sponsor: Department of medicine, Dermatology unit, Chulalongkorn university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-22
• Study Completion: 2015-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

chronic spontaneous urticaria patient with active symptoms rash for 2 days week or more
age 18 80 years

Exclusion Criteria

pregnancy or lactation
history of rash on velar forearms within 48 hours before testing
on any antihistamine within 3 days prior to the test 4 days for Dexchlorpheniramine levocetirizine 7 days for Azelastine Loratadine or other long acting antihistamines 2 weeks for doxepin
history of potent topical steroids class 1 3 application on the volar forearms or systemic corticosteroid dosing equivalent to prednisolone 15 mg d within 7 days prior to the test
have physical urticaria or dermatographism
have urticarial vasculitis urticaria from other autoimmune connective tissue disease autoimmune progesterone urticaria or positive progesterone intradermal testing
have abnormal CBC hepatitis virus infection abnormal stool examination urinary analysis chest radiograph rheumatoid factor level or antinuclear antibody titer more than 1 80

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
positive rates of the autologous serum skin test compared with the autologous plasma skin test 30 min after intradermal injection wheal response to autologous serum/ plasma 1.5 mm or more compared with saline

Secondary Outcome Measures

Name	Time	Method
accuracy of ASST compared with APST in detecting positive BHRA, antiFcERIa antibody - sensitivity, specificity, predictive values, accuracy,agreement between BHRA and antiFcERIa in chronic spontaneous urticaria - Cohen's kappa coefficient