NCT01315093已完成2 期
Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- no of oocytes retrieved
研究概览
简要总结
The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 25 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •poor responders (age>40, abnormal ovarian test, </=4 oocytes in previous cycle with conventional stimulation)
- •infertility, indication for IVF
- •no contraindications for heparin
排除标准
- 未提供
研究组 & 干预措施
Heparin, Low-Molecular-Weight group
Experimental
LMWH was administered during an IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. Drug was started at the beginning of the cycle and stopped at the time of pregnancy test if negative, or continued if pregnancy occurred until the 32th weeks of gestation
干预措施: Heparin, Low-Molecular-Weight (Drug)
Non Heparin, Low-Molecular-Weight group
Active Comparator
IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders.
干预措施: no heparin (Drug)
结局指标
主要结局
no of oocytes retrieved
时间窗: egg recovery, 2 years
\>2 between groups
次要结局
- miscarriage rate(2 years)
- clinical pregnancy rate(2 years)
- live birth rate(2 years)
- cancellation rate(before ET, 2 years)
研究者
Siristatidis Charalampos, MD, PhD
Assistant Professor, Director of the ARU
National and Kapodistrian University of Athens
研究点 (1)
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