Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation
Phase 2
Completed
- Conditions
- Infertility
- Interventions
- Drug: Heparin, Low-Molecular-Weight
- Registration Number
- NCT01315093
- Lead Sponsor
- National and Kapodistrian University of Athens
- Brief Summary
The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
- poor responders (age>40, abnormal ovarian test, </=4 oocytes in previous cycle with conventional stimulation)
- infertility, indication for IVF
- no contraindications for heparin
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Non Heparin, Low-Molecular-Weight group no heparin IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. Heparin, Low-Molecular-Weight group Heparin, Low-Molecular-Weight LMWH was administered during an IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. Drug was started at the beginning of the cycle and stopped at the time of pregnancy test if negative, or continued if pregnancy occurred until the 32th weeks of gestation
- Primary Outcome Measures
Name Time Method no of oocytes retrieved egg recovery, 2 years \>2 between groups
- Secondary Outcome Measures
Name Time Method miscarriage rate 2 years pregnancy loss \<20 weeks
clinical pregnancy rate 2 years Presence of fetal heart at transvaginal ultrasound at 6+2 gestational weeks
live birth rate 2 years \>20 weeks of gestation
cancellation rate before ET, 2 years
Trial Locations
- Locations (1)
3rd Department of Obstetrics & Gynecology
🇬🇷Athens, Chaidari, Greece