Estimate the Relationship Between Oral Microbiota and Stroke

Recruiting

• Conditions: Stroke; Microbial Disease

• Registration Number: NCT06479915
• Lead Sponsor: Fujian Medical University

Brief Summary

Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups.

Detailed Description

Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups. The objective of this study is to offer novel insights into the association between oral health and cerebrovascular disease occurrence while establishing a foundation for future research.

Study Timeline

• Study Start: 2024-04-01
• Study First Submitted: 2024-06-19
• Study First Submitted QC: 2024-06-26
• Study First Posted: 2024-06-28
• Primary Completion: 2025-02-28
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-12
• Last Update Posted: 2025-03-14
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• 1. Microbleeding/damage or rupture of small blood vessels in the brain has been diagnosed within the past 365 days 2. Have done nuclear magnetic examination and can provide nuclear magnetic results

Exclusion Criteria

• Have received antibiotic quality within the last three months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation Between Oral Microbiota and Cerebral Microbleeds in Stroke	2025.06	Number and volume of microbleeds (measured in mm³)
Estimate the Relationship Between Oral Microbiota and Stroke	2025.06	Measure the diversity and abundance of oral bacteria in stroke patients,units:Number of bacterial species, bacterial counts (CFU/ml)

Trial Locations

Locations (2)

School and Hospital of stomatology,Fujian Medical University,Fuzhou,Fujian Province,350002,China; 🇨🇳 Fuzhou, Fujian, China

The First Affiliated Hospital of Fujian Medical University; 🇨🇳 Fuzhou, Fujian, China