Disease Profile of Dengue Fever in AIIMS Rishikesh (DPDF study)

Recruiting

Conditions: Dengue fever [classical dengue],

Registration Number: CTRI/2020/02/023617

Lead Sponsor: AIIMS Rishikesh

Brief Summary: Justification for study:

Hundreds of thousands of dengue cases are reported worldwide each year. Given the difficulty in full reporting, the actual number of human infections is probably much higher than the number reported. Dengue is usually a nonspecific febrile illness that resolves with supportive therapy but the clinical spectrum ranges from asymptomatic infection through severe hemorrhage and sudden fatal shock into expanded dengue syndrome. The pathophysiology of the severe forms of dengue may be related to sequential infection with different serotypes, variations in virus virulence, interaction of the virus with environmental and host factors, or a combination of these factors. Control of dengue at the present time is dependent on control of the principal vector mosquito, A. aegypti. Vaccine development continues, but at present the only way to avoid dengue in an area where it is endemic or epidemic is to use repellents and mosquito barriers. The movement of people to and from tropical areas makes dengue an important differential diagnosis in any patient with an acute illness and history of recent travel to tropical areas. Recently, the disease is clearly documented to have re-emerged on this subcontinent but, with an expanded spectrum of clinical manifestations and complications, as observed in clinical experience. There are also regional differences in the clinical spectrum observed within India, probably due to antigenic variation of the organism. Therefore, it is important to study the demographical factors contributing to the disease occurrence, clinical presentations including their variability, laboratory details, treatment particulars and outcomes of the dengue fever in this region. This will improve the knowledge on this expanding clinical syndrome in our region.

Scope of the project:

This is intended to develop preliminary Indian current data on the various aspects of course of illness of dengue fever. There seems to have a good scope to optimize and improve the existing practice in the current empirical antibiotic era. The atypical manifestations will be described and predictors of mortality will be identified. Largely, the database of dengue will be created for this region and it will help in planning many future studies.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 500

Inclusion Criteria

1.All serological positive dengue cases (both children and adult) for next two years 2.Clinical diagnosis of dengue 3.Patient medical records available from July 2017 to present time for retrospective cohort.

Exclusion Criteria

1.Positive cases who have been admitted in other than medicine/pediatric dept where medicine/padiatric reference has not been sorted respectively.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To describe the demographical, clinical, laboratory, treatment, and outcome details of dengue fever patients at AIIMS	Selection of cases: From July 2017 to present time for retrospective cases and for next 2-years for prospective cases
2.To describe expanded dengue syndrome variants in same cohort	Selection of cases: From July 2017 to present time for retrospective cases and for next 2-years for prospective cases
4.To determine the predictors of morbidity and mortality in same cohort	Selection of cases: From July 2017 to present time for retrospective cases and for next 2-years for prospective cases
3.To determine Himalayan and sub-himalayan variation in same cohort	Selection of cases: From July 2017 to present time for retrospective cases and for next 2-years for prospective cases

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): AIIMS
🇮🇳
Dehradun, UTTARANCHAL, India
AIIMS
🇮🇳Dehradun, UTTARANCHAL, India
Dr Prasan Kumar Panda
Principal investigator
9868999488
prasan.med@aiimsrishikesh.edu.in