Anesthesia and Cancer Study: Colon Cancer

Not Applicable

Active, not recruiting

• Conditions: Anesthesia; Cancer of Colon
• Interventions: Drug: Propofol; Drug: Sevoflurane

• Registration Number: NCT04259398
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Detailed Description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Study Timeline

• Study First Submitted: 2020-02-04
• Study First Submitted QC: 2020-02-04
• Study First Posted: 2020-02-06
• Study Start: 2020-02-18
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-20
• Last Update Posted: 2023-11-22
• Primary Completion: 2028-05-03
• Study Completion: 2028-05-03

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 797

Inclusion Criteria

• adults undergoing surgery to remove colon cancer

Exclusion Criteria

• pregnancy
• colon cancer with invasion to perineum
• palliative surgery
• history of diagnosis or surgery for other cancer
• emergent surgery
• ASA PS classification 4 and 5
• refusion to participate in the study
• allergy to anesthetics

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TIVA	Propofol	propofol infusion targeting bispectral index 40-60
inhalation (Sevoflurane)	Sevoflurane	sevoflurane targeting bispectral index 40-60

Primary Outcome Measures

Name	Time	Method
five year survival	five years survival	survival rate regardless of recurrence

Secondary Outcome Measures

Name	Time	Method
3 year survival	3 years after surgery	survival regardless of recurrence
five year recurrence free survival	five years after surgery	survival rate without recurrence
1 year survival	1 year after surgery	survival regardless of recurrence
1 year recurrence free survival	1 year after surgery	survival rate without recurrence
3 year recurrence free survival	3 years after surgery	survival rate without recurrence

Trial Locations

Locations (2)

Seoul Metropolitan Government Seoul National University Boramae Medical Center; 🇰🇷 Seoul, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of