Evaluation of Repeated Botulinum Toxin A Applications According To Different Anesthesia Types and Gross Motor Function in Children With Cerebral Palsy
- Conditions
- cerebral palsyNeurological - Other neurological disordersMusculoskeletal - Other muscular and skeletal disordersAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12621001744842
- Lead Sponsor
- niversity of Health Sciences Izmir Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital
- Brief Summary
Research question: The question of this research is what the effect of different anesthesia types applied on functional results in patients who underwent repetitive Botulinum toxin A. Background information: Botulinum toxin A is a substance that requires repeated application due to its effectiveness being lost 12-16 weeks post application. This study evaluates motor development of patients undergoing 3 or more repeated BoNT-A application in a tertiary pediatric hospital and the safety as well as effect of 3 different types of anesthesia. Participant characteristics: Spastic hemiplegic cerebral palsy patients who applied to the orthopedic clinic of our hospital for botox application in the last 10 years and who underwent BoNT-A application at least 3 times under anesthesia in operating room conditions will be included in the study. Key results: When compared with other anesthesia types, it was observed that the application of sedation significantly shortened the recovery and total operating room time in the first three applications. However, in the repeated applications, it was observed that the duration of anesthesia was prolonged in those who underwent sedation, as in masks and LMAs. It was thought that this situation, which was observed regardless of the type of anesthesia, might be related to drug tolerance. Limitation: The most important limitation is the retrospective nature of the study. The lack of randomized anesthesia method selection is another limitation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 75
Spastic hemiplegic cerebral palsy patients who applied to the orthopedic clinic of our hospital for botox application in the last 10 years and underwent botulinum toxin A application under anesthesia in operating room conditions will be included in the study.
Patients who underwent botulinum toxin A in the orthopedic clinic of our hospital between January 2008 and January 2018 were included in the study.
Patients who received BoNT-A once or twice between January 2008 and January 2018 were excluded from the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method