Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy

Not Applicable

Recruiting

• Conditions: Postoperative Nausea and Vomiting; Laparoscopic Cholecystectomy
• Interventions: Drug: Ginger; Drug: Placebo

• Registration Number: NCT07190495
• Lead Sponsor: University Tunis El Manar

Brief Summary

This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-07-05
• Status Verified: 2025-09
• Study First Submitted: 2025-09-14
• Study First Submitted QC: 2025-09-19
• Last Update Submitted: 2025-09-19
• Study First Posted: 2025-09-24
• Last Update Posted: 2025-09-24
• Primary Completion: 2026-06
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Age ≥ 18 years.
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
• American Society of Anesthesiologists (ASA) physical status I-III.
• Able to understand the study procedures and provide written informed consent.

Exclusion Criteria

• Known allergy or hypersensitivity to ginger
• Documented history of bleeding disorders or current treatment with anticoagulant agents
• History of severe postoperative nausea and vomiting or an Apfel score of 4
• Administration of antiemetic drugs or corticosteroids during the preoperative period
• Pregnancy or breastfeeding
• Active gastrointestinal or liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ginger group	Ginger	Patients will receive 800 mg of oral ginger 2 hours before laparoscopic cholecystectomy
Placebo group	Placebo	Patients will receive an oral placebo capsule identical in appearance to ginger, administered 2 hours before laparoscopic cholecystectomy

Primary Outcome Measures

Name	Time	Method
Incidence of postoperative nausea and vomiting (PONV) within 2 hours post-surgery	2 hours after surgery.	Occurrence of at least one episode of nausea or vomiting within the first 2 hours after surgery.

Secondary Outcome Measures

Name	Time	Method
Recurrence of PONV beyond 2 hours postoperatively	From 2 hours to 24 hours after surgery.	Proportion of participants who experienced at least one additional episode of nausea or vomiting occurring after the 2-hour postoperative time point.
Incidence of postoperative nausea and vomiting (PONV) within 24 hours post-surgery	24 hours after surgery.	Occurrence of at least one episode of nausea or vomiting within the first 24 hours after surgery.
Total number of vomiting episodes	Within 24 hours post-surgery.	Cumulative number of vomiting episodes recorded per participant during the first 24 hours after surgery.
Use of rescue antiemetics	24 hours postoperatively	The need for rescue antiemetics within 24 hours postoperatively.
Incidence of ginger-related adverse events	Within 24 hours after surgery	Number of participants experiencing adverse events known to be associated with ginger, including gastrointestinal discomfort (heartburn, abdominal pain, bloating, diarrhea), bleeding, or allergic reactions in the 24 hours after surgery.

Trial Locations

Locations (1)

Mohamed Taher Maamouri University Hospital; 🇹🇳 Nabeul, Nabeul Governorate, Tunisia