Immunological determinants of human embryo implantation: an ex vivo model

Recruiting

• Conditions: implantation; infertility; 10029112; 10000211; 10013356

• Registration Number: NL-OMON29908
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 280

Inclusion Criteria

IVF or ICSI treatment

Exclusion Criteria

None

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The surplus embryos will be cultured on a layer of endometrial stromal cells.<br /><br>The process of adhesion and invasion will be closely followed by measurements<br /><br>of cytokine and trophic factors in culture media, which will provide<br /><br>information on stromal invasion. Main study parameters will be the extent of<br /><br>trophoblast invasion and the cytokine and trophic factor profile of daily<br /><br>produced affluent. Study endpoint will be day 10 of embryo development. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The correlation of cytokine/trophic factor patterns expressed in (autologous<br /><br>co-) culture media from normal and abnormal stromal invading embryos.<br /><br>- To investigate whether the chromosomal constitution of the embryo is related<br /><br>to a specific pattern of cytokine expression and implantation.</p><br>