The effect of a 2-week preoperative vegan diet versus omnivorous diet on the protein turnover in the osteoarthritic knee

• Conditions: knee wear and tear; osteoarthritis in the knee; 10043237

• Registration Number: NL-OMON56530
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Written informed consent;
- Male and female patients scheduled for total knee arthroplasty;
- BMI between 20-32 kg/m2;
- Aged 60 - 80 years;
- Mentally competent, as judged by the treating physician.

Exclusion Criteria

- Following a vegetarian or vegan diet or a diet that affects protein intake
during the six months prior to the study;
- Participating in a structured exercise training program in the past three
months;
- Lost more than 4 kg body weight during three months prior to the study;
- Chronic use of medications that affect protein metabolism (i.e. systemic
corticosteroids, or prescription strength acne medications);
- Being diagnosed with one of the following: diabetes mellitus, rheumatoid
arthritis, peripheral artery disease Fontaine III or IV, COPD GOLD III or IV,
phenylketonuria, collagen disorders (e.g. Marfan and Ehler-Danlos);
- Receiving neoadjuvant chemotherapy or radiotherapy;
- Alcohol abuse (for men 15 or more alcoholic drinks per week and for women 8
or more alcoholic drinks per week);
- Surgical intervention to the knee in the past four weeks;
- Total parenteral nutrition at day of surgery;
- Glomerular filtration rate (GFR) <20 mL/min/1.73 m2;
- Allergic or intolerant to any product included in the diets;
- Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis,
fracture, osteochondritis dissecans, or malignant processes;
- Any other medical condition that may interfere with the safety of the
participants or the outcome parameters, in the investigators judgement;
- Not willing to stop nutritional supplements, with the exception of vitamin D
and supplements on medical advice.
- Investigator*s uncertainty about the willingness or ability of the
participant to comply with the protocol instructions;
- Participation in other studies that may have an impact on the outcomes during
the three months before the start of the current study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are protein synthesis rates of Hoffa*s fat pad,<br /><br>synovium, bone, ligament, menisci, and cartilage. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters include blood pressure, and plasma amino acids.</p><br>