Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling
- Conditions
- Heart FailureHeart Failure (for Example, Fluid Overload)
- Registration Number
- NCT07158086
- Lead Sponsor
- University of Zurich
- Brief Summary
The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling. By integrating clinical data with cutting-edge multi-omics techniques (including transcriptomics, epigenomics, and proteomics), this research aims to identify molecular signatures, particularly non-coding RNAs (ncRNAs), that are linked to the onset and progression of HF. Through advanced molecular profiling of biological samples and the analysis of clinical parameters, including advanced imaging, hemodynamic profiling, and biomarker analysis, the study will contribute to the deep phenotyping of HF patients.
The secondary objective aims to uncover potential biomarkers that may serve as predictive indicators of disease progression and identify novel therapeutic targets, offering promising avenues for future treatments in this challenging patient population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 500
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death from any cause From enrollment up to five years Heart failure hospitalization From enrollment up to five years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital of Zurich
🇨🇭Zurich, Switzerland
University Hospital of Zurich🇨🇭Zurich, SwitzerlandJan A Kleeberger, MDPrincipal InvestigatorLudovica Di Venanzio, MDSub Investigator