Cognitive Behavioral Therapy Plus Drug Treatment for Obsessive Compulsive Disorder

Not Applicable

Completed

• Conditions: Obsessive-Compulsive Disorder
• Interventions: Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy); Behavioral: Stress Management Therapy (Cognitive Behavior Therapy)

• Registration Number: NCT00045903
• Lead Sponsor: New York State Psychiatric Institute

Brief Summary

This study will evaluate the effectiveness of two cognitive behavioral therapies (CBTs) in treating obsessive compulsive disorder (OCD) in patients who are taking medication but still have residual symptoms.

Detailed Description

Participants remain on their current OCD medication and are randomly assigned to receive one of two CBTs: exposure and ritual prevention or stress management therapy. Exposure and ritual prevention involves imaginal and in-vivo exposure and requires that participants refrain from ritualizing. Stress management involves relaxation, assertiveness training, and structured problem-solving. Therapy occurs twice per week for 2 months. Participants are assessed verbally by an independent evaluator and are asked to complete self-rating forms. Patients who respond are followed for up to 1 additional year. Participants continue to take the same medication and the same monthly therapy for the first 6 months of follow-up. During the second 6 months of follow-up, participants discontinue therapy but continue taking the same medication.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00389493

Study Timeline

• Study Start: 2000-08
• Study First Submitted: 2002-09-13
• Study First Submitted QC: 2002-09-16
• Study First Posted: 2002-09-17
• Primary Completion: 2007-01
• Study Completion: 2007-01
• Status Verified: 2012-10
• Last Update Submitted: 2014-04-22
• Last Update Posted: 2014-04-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 136

Inclusion Criteria

• Obsessive-Compulsive Disorder (OCD) diagnosis
• Currently taking a serotonin reuptake inhibitor (SRI, i.e. clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline, or citalopram) for OCD

Exclusion Criteria

• Medical or psychiatric conditions that would make participation in the study hazardous
• Intensive cognitive-behavioral therapy while on an adequate dose and duration of an SRI for OCD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exposure and Ritual Prevention	Exposure and Ritual Prevention (Cognitive Behavioral Therapy)	Exposure and Ritual Prevention Therapy
Stress Management	Stress Management Therapy (Cognitive Behavior Therapy)	Stress Management Therapy

Primary Outcome Measures

Name	Time	Method
Obsessive-compulsive symptoms measured at Month 2	2 months

Secondary Outcome Measures

Name	Time	Method
General functioning measured at Month 2	2 months

Trial Locations

Locations (2)

University of Pennsylvania Center for the Treatment and Study of Anxiety; 🇺🇸 Philadelphia, Pennsylvania, United States

New York State Psychiactic Institute, Anxiety Disorders Clinic; 🇺🇸 New York, New York, United States