The Use of Platelet-rich-fibrin in Lower Third Molar Surgery: a Split-mouth Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Facial Swelling
- Sponsor
- Amerigo Giudice
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Facial swelling qualitative analysis
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.
Detailed Description
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.
Investigators
Amerigo Giudice
Professor
University Magna Graecia
Eligibility Criteria
Inclusion Criteria
- •Patients aged 18 to 32 years who required both M3M extractions were recruited
- •Good health status
- •Indication to surgical extraction of both M3M
- •Complete root formation
- •Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification
Exclusion Criteria
- •Person under the age of 18 or over 32
- •Allergy or contraindications to administration of corticosteroids
- •Acute infection in any of the teeth to be extracted
- •Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease
- •Pregnancy or breastfeeding
- •History of treatment with antiresorptive drugs
- •Chronic kidney disease
Outcomes
Primary Outcomes
Facial swelling qualitative analysis
Time Frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
To compare the effectiveness of PRF in reducing facial swelling using qualitative three-dimensional analysis (measured by colorimetric variation given by the overlapping volumes) .
Facial swelling quantitative analysis - volumetric differences
Time Frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis ( volumes measured in cm3) .
Facial swelling quantitative analysis - linear differences
Time Frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis (linear differences measured in cm2) .
Secondary Outcomes
- Trismus analysis(Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery)
- Pain analysis with Visual analogue scale (VAS)(Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery)