The Glycemic Response Elicited by Beta-glucans of Different Physical Properties and Form
- Conditions
- Type 2 Diabetes
- Interventions
- Dietary Supplement: oat beta-glucanDietary Supplement: Placebo
- Registration Number
- NCT01610518
- Lead Sponsor
- Guelph Food Research Centre
- Brief Summary
The ability of oat β-glucan to lower postprandial glycemic responses has been attributed to the viscosity of the solution in which the fibre is solubilized. To our knowledge, no studies have investigated the effect of β-glucan solutions on glycemic response when concentration, and thus viscosity, is varied by changing the solution volume but not the β-glucan dose. Therefore, the investigators will test the effects of altering β-glucan solution viscosity by altering solution volume at a fixed amount of β-glucan fibre.
- Detailed Description
The ability of β-glucan to lower postprandial glycemic responses has been attributed to the viscosity of the solution in which the fibre is solubilized. It has been demonstrated that the viscosity of a β-glucan solution increases with the molecular weight (MW) of β-glucan polymers, as well as the dose or concentration (C) of those polymers in solution. Numerous studies have shown that glycemic response-lowering is strengthened when the C of a β-glucan solution of fixed liquid volume is increased by increasing β-glucan dose. However, the C of a β-glucan solution depends on not only the amount of fibre present but also on the solution volume. To our knowledge, no studies have investigated the effect of β-glucan solutions on glycemic response when C, and thus viscosity, is varied by changing the solution volume but not the β-glucan dose. Therefore, the investigators will test the effects of altering β-glucan solution viscosity by altering solution volume at a fixed amount of β-glucan fibre. Knowing how to incorporate β-glucan into solution so that its physiological benefits are preserved will assist in the development of β-glucan-containing functional foods.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
- healthy men and women
- BMI greater than or equal to 35
- known to have diabetes, HIV, hepatitis or a heart condition
- use of medications or having a condition which may harm the subjects
- use of medication which may affect the study results
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 250 mL medium viscosity oat beta-glucan 250 mL beverage containing 4g low molecular weight oat beta-glucan and 50g glucose 600 mL low viscosity oat beta-glucan 600 mL beverage containing 4g low molecular weight oat beta-glucan and 50g glucose 250 mL high viscosity oat beta-glucan 250 mL beverage containing 4g high molecular weight oat beta-glucan and 50g glucose 600 mL medium viscosity oat beta-glucan 600 mL beverage containing 4g high molecular weight oat beta-glucan and 50g glucose 250mL control Placebo 250 mL beverage containing 50g glucose 600mL control Placebo 600mL beverage containing 50g glucose
- Primary Outcome Measures
Name Time Method postprandial blood glucose 2 h Two fasting blood samples spaced 5 minutes apart (-5 min and 0 min) were collected by finger-prick using a monoejector lancet device. Immediately following the collection of the second blood sample, subjects consumed a test solution and 250mL of a beverage of their choice (water, tea or coffee with milk and/ or artificial sweetener aspartame). Subjects received the same beverage and volume of that beverage for each test in the study. Additional finger-prick blood samples were taken at 10, 20, 30, 40, 50, 60, 90 and 120 minutes after the start of the meal.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
GILabs
🇨🇦Toronto, Ontario, Canada