A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- Cytomegalovirus RetinitisHIV Infections
- Registration Number
- NCT00002330
- Lead Sponsor
- Roche Global Development
- Brief Summary
To compare the time to progression of Cytomegalovirus (CMV) retinitis among each of three doses of oral ganciclovir, as well as to intravenous therapy, when given as maintenance for 26 weeks. To compare the safety and tolerance among oral doses of ganciclovir at the study doses, as well as to intravenous therapy, when administered as maintenance for 26 weeks.
- Detailed Description
Patients who have received anti-CMV therapy with intravenous ganciclovir for at least 4 weeks that resulted in stable retinitis are randomized to receive one of three doses of oral ganciclovir or intravenous ganciclovir for 26 weeks of maintenance.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 280
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (36)
Dr Ken Fisher
🇺🇸Phoenix, Arizona, United States
Dr Daniel Barbero
🇺🇸Fort Worth, Texas, United States
Saint Luke's - Roosevelt Hosp Ctr
🇺🇸New York, New York, United States
Nalle Clinic
🇺🇸Charlotte, North Carolina, United States
Univ of Maryland School of Medicine
🇺🇸Baltimore, Maryland, United States
Margo Heath - Chiozzi
🇺🇸Honolulu, Hawaii, United States
McDowell Clinic
🇺🇸Phoenix, Arizona, United States
UCSD Med Ctr / Pediatrics
🇺🇸San Diego, California, United States
Mount Zion Med Ctr / UCSF
🇺🇸San Francisco, California, United States
Case Western Reserve Univ
🇺🇸Cleveland, Ohio, United States
Univ of Alabama at Birmingham / AIDS Outpatient Clinic
🇺🇸Birmingham, Alabama, United States
Portland Veterans Adm Med Ctr / Rsch & Education Grp
🇺🇸Portland, Oregon, United States
AIDS Clinical Trials Unit
🇺🇸St. Louis, Missouri, United States
N Texas Ctr for AIDS & Clin Rsch
🇺🇸Dallas, Texas, United States
Univ of Arizona / Health Science Ctr
🇺🇸Tucson, Arizona, United States
San Francisco Veterans Administration Med Ctr
🇺🇸San Francisco, California, United States
Univ of North Carolina School of Medicine
🇺🇸Chapel Hill, North Carolina, United States
Audie L Murphy Veterans Administration Hosp
🇺🇸San Antonio, Texas, United States
AIDS Research Consortium of Atlanta
🇺🇸Atlanta, Georgia, United States
Univ of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Buckley Braffman Stern Med Associates
🇺🇸Philadelphia, Pennsylvania, United States
East Bay AIDS Ctr
🇺🇸Berkeley, California, United States
AIDS Clinical Research Ctr / UCLA Med Ctr
🇺🇸Los Angeles, California, United States
Davies Med Ctr
🇺🇸San Francisco, California, United States
Austin Infectious Disease Consultants
🇺🇸Austin, Texas, United States
Dr Dorothy Friedberg
🇺🇸New York, New York, United States
New York Hosp - Cornell Med Ctr
🇺🇸New York, New York, United States
HIV Wellness Ctr / Univ Med Ctr
🇺🇸Las Vegas, Nevada, United States
Ohio State Univ Hosp
🇺🇸Columbus, Ohio, United States
AIDS Wellness Clinic
🇺🇸Sante Fe, New Mexico, United States
Associates Med and Mental Health
🇺🇸Tulsa, Oklahoma, United States
George Washington Univ Med Ctr
🇺🇸Washington, District of Columbia, United States
Texas Tech Health Sciences Ctr
🇺🇸El Paso, Texas, United States
Saint Paul's Hosp
🇨🇦Vancouver, British Columbia, Canada
Community Research Initiative
🇺🇸Coral Gables, Florida, United States
Infectious Diseases Association of Houston
🇺🇸Houston, Texas, United States