Effects of metformin in the treatment of endometrial hyperplasia
- Conditions
- endometrial hyperplasia.Hyperplasia of endometrium: NOS cystic glandular-cystic polypoid
- Registration Number
- IRCT2014082018866N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 64
In this randomized clinical trial of patients with endometrial hyperplasia admitted to Arash hospital, Tehran, Iran in 2014 were diagnosed by biopsy sample were recruited. women aged 18 to 75 years old with endometrial biopsy confirmed by endometrial hyperplasia; no contraindications to treatment with metformin; creatinine clearance greater than 90ml / min; using the formula of Cockroft-Gault; normal hepatic markers hemoglobin level above 10; satisfactory condition; physically fit to participate in the study. Exclusion criteria: taking metformin within the past 6 months; impaired hepatic function tests, blood sugar is less than 65 and no more than 200; history of alcohol use disorder; history of vitamin B12; pregnancy; history of insulin therapy; body mass index less than 25.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of endometrial hyperplasia. Timepoint: befor treatment,3 months after start treatment. Method of measurement: Review of Pathology.
- Secondary Outcome Measures
Name Time Method Evaluation of the hepatic effects of metformin in the treatment of patients with Endometrial hyperplasia. Timepoint: start of treatment and 3 months after that. Method of measurement: blood sampling and liver tests measurements.;Reviews of metformin renal complications in the treatment of patients with Endometrial hyperplasia. Timepoint: start teatment and 3 months after that. Method of measurement: blood sampling and measuring hepatic function test.;Effect of metformin in reduce blood glocose. Timepoint: start treatment and 3 months after that. Method of measurement: blood sampling and Blood glucose measurement.;Effect of metformin on body mass index. Timepoint: start treatment and 3 months after that. Method of measurement: Measurement of height and weight and body mass index calculator.