Exploring the importance of genome sequencing to predict pneumonia in childre
- Conditions
- Health Condition 1: J00-J99- Diseases of the respiratory system
- Registration Number
- CTRI/2022/10/046763
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Case
Cases are hospitalized children aged <18 years with World Health Organization (WHO)-defined severe or very severe pneumonia (using pre-2013 definitions) and who are not initiated on any antibiotics.
Control
Children less than 18 years belonging to the same family who are healthy and not suffering from any disease. If siblings are absent, healthy children from the neighborhood will be included.
Case
Cases were excluded if they had been hospitalized within the previous 14 days or had resolution of lower chest wall indrawing following bronchodilator therapy (for severe cases with wheeze) or had one course of antibioticsâ??children with immune-compromised status such as HIV.
Control
Children with any kind of illness or any history of antibiotics or drug intake in the last one week
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a. Metagenomic comparison of pediatric pneumonia cases with healthy children. <br/ ><br>b. Detection and surveillance of AMR genes in children less 18 years of age. <br/ ><br> <br/ ><br>Timepoint: 2 years <br/ ><br>
- Secondary Outcome Measures
Name Time Method a. Comparing the microbiota of pediatric pneumonia cases based on etiology. <br/ ><br>b. Detection of TB bacilli if present <br/ ><br>Timepoint: 2 years