One night of partial sleep restriction: effects on metabolism, mood and stress responsiveness

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 33

Inclusion Criteria

- Informed consent
- Caucasian men
- Age between 18 and 55 years
- BMI between 20 and 25 kg/m2 (equally divided over the range, so ideally n=12 in BMI categories 20 -25; 25 - 30; 30 - 35 kg/m2)

Exclusion Criteria

Active endocrine disease (e.g. diabetes mellitus type 1 and type 2, thyroid disease, Cushing*s disease and lipid-associated disorders such as FH)
- Fasting glucose >7.0 mmol/L
- Severe chronic disease (e.g. chronic liver or kidney disease)
- Severe insomnia, sleep disorders or exceptional habitual sleep duration (<6 or >10 h).
- Medication use including the following: lipid lowering drugs, glucocorticoids, sleep medication, hormone replacement, glucose lowering drugs, insulin therapy (last 6 weeks), anticoagulants
- Recent time zone travel (last 6 weeks)
- Shift work (last 6 weeks)
- Severe alcohol use (>21 units/week)
- Psychiatric disease
- Drug abuse
- Recent participation to another nutritional or biomedical trial (last 6 weeks)
- Taking medication, which may interfere with study measurements, as judged by the responsible physician
- Reported weight loss or weight gain (10%) in the last six months prior to the pre-study screening
- Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician)
- Reported use of any nicotine containing products in the six months preceding the study and during the study itself;
- Extreme strenuous exercise during last 3 months, as judged by responsible physician
- Excessive sunbathing during the last 3 months, as judged by responsible physician

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primairy study parameters are:<br /><br>- Lipid metabolism by measurement of hormone and lipid concentrations in plasma<br /><br>in response to a mixed-meal challenge<br /><br>- Energy metabolism by measurement of indirect calorimetry<br /><br>- HPA-axis responsiveness by hormone and blood pressure measurement during a<br /><br>cold- feet pressor test<br /><br>- Mood via short questionnaires (Profile of Mood States)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondairy study parameters are:<br /><br>- Gene expression profiles and metabolomics in muscle and fat tissue and plasma<br /><br>- Gene expression profiles in skin and hair samples</p><br>

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