One night of partial sleep restriction: effects on metabolism, mood, and stress responsiveness
- Conditions
- SleepmetabolismmoodstressSlaapmetabolismestemmingstress
- Registration Number
- NL-OMON25362
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Donga,E., van,D.M., van Dijk,J.G., Biermasz,N.R., Lammers,G.J., van Kralingen,K.W., Corssmit,E.P., and Romijn,J.A. (2010a). A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol. Metab 95, 2963-2968. Donga,E., van,D.M., van Dijk,J.G., Biermasz,N.R., Lammers,G.J., van,K.K., Hoogma,R.P., Corssmit,E.P., and Romijn,J.A. (2010b). Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes Care 33, 1573-1577.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 36
Informed consent
-Male Caucasian
- Active endocrine disease (e.g. diabetes mellitus type 1 and type 2, thyroid disease, any signs of Cushing’s syndrome, adrenal disease and lipid-associated disorders such as FH)
- Fasting glucose >7.0 mmol/L
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Metabolic flexibility; measured as change in RQ and lipid levels after a standard meal<br /><br>- Stress responsiveness; measured as change in stress hormones, heart rate and blood pressure after a mild physical stressor<br>
- Secondary Outcome Measures
Name Time Method - Tissue ageing; measured in skin<br /><br>- Intracellular metabolic pathways; measured in subcutaneous white fat and skeletal muscle tissue<br /><br>- Circadian rhythm in hormone and skin temperature rhythms