The effectiveness of intravenous dexamethasone prophylaxis before thyroidectomy in reducing postoperative pain, nausea and vomiting

Phase 4

Completed

• Conditions: patients who underwent thyroid surgery in Hua Hin Hospital; dexamethasone, postoperative pain, postoperative nausea and vomiting, effectiveness

• Registration Number: TCTR20230510003
• Lead Sponsor: Hua Hin Hospital

Brief Summary

In dexamethasone group, the mean pain score is significantly lower at recovery room admission and postoperative nausea and vomiting incidence is significantly lower at one hour after surgery compare to placebo group. No significantly differences in pain score and nausea and vomiting score at eight hours after surgery.

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-03-31
• Study Start: 2023-05-10
• Results First Posted: 2023-12-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients age 18-65 years who underwent thyroid surgery, 2. ASA class 1 or 2, 3. Ideal Body Weight 40-80 kilogram

Exclusion Criteria

1. Patients with previous thyroid or neck surgery, 2. antiemetic consumption within 48 hours before surgery, 3. history of chronic pain, 4. history of DM or preoperative blood glucose more than 126 mg/dL, 5. history of postoperative nausea and vomiting, 6. pregnancy or lactation, 7. history of allergic reaction to medication used in this research, 8. history of underlying diseases that may be worsen by dexamethasone administration i.e. gastric ulcer

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pain at 0, 1, 8 hours after surgery numerical rating scale

Secondary Outcome Measures

Name	Time	Method
nausea and vomiting at 0, 1, 8 hours after surgery PONV score