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Dual Site-dual Channel Non-invasive Brain Stimulation for Motor Function in Stroke Patients

Not Applicable
Completed
Conditions
Stroke
Interventions
Device: M1 stimulation
Device: PMC stimulation
Device: aIPS stimulation
Behavioral: hand motor task
Registration Number
NCT03486769
Lead Sponsor
Samsung Medical Center
Brief Summary

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
30
Inclusion Criteria
  • unilateral hemiplegic stroke patient
  • Fugl Meyer Assessment score between 9 to 84
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Exclusion Criteria
  • difficult to understand experimental tasks because of extremely severe cognitive impairment
  • history of psychiatric disease
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Dual Stimulation 1hand motor taski) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area.
Dual Stimulation 1PMC stimulationi) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area.
Single stimulationhand motor taskanodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex
Dual Stimulation 1M1 stimulationi) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area.
Dual Stimulation 2hand motor taski) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area.
Dual Stimulation 2aIPS stimulationi) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area.
Dual Stimulation 2M1 stimulationi) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area.
Single stimulationM1 stimulationanodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex
Primary Outcome Measures
NameTimeMethod
Changes in motor evoked potentiaBaseline and after intervention (approximately 2 weeks)

measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle.

Secondary Outcome Measures
NameTimeMethod
changes in grip and tip pinch strength testBaseline and after intervention (approximately 2 weeks)

measure the hand strength (grip and tip pinch)

Changes in brain activation of resting-state functional MRIBaseline and after intervention (approximately 2 weeks)

Neuroplasticity measure

changes in nine hole peg testBaseline and after intervention (approximately 2 weeks)

Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses.

Changes of Cortical activationBaseline and after intervention (approximately 2 weeks)

Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany)

changes in box and block testBaseline and after intervention (approximately 2 weeks)

box and block test measures unilateral gross manual dexterity

Trial Locations

Locations (1)

Samsung Medical Center

🇰🇷

Seoul, Korea, Republic of

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