Dual Site-dual Channel Non-invasive Brain Stimulation for Motor Function in Stroke Patients
- Conditions
- Stroke
- Interventions
- Device: M1 stimulationDevice: PMC stimulationDevice: aIPS stimulationBehavioral: hand motor task
- Registration Number
- NCT03486769
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- unilateral hemiplegic stroke patient
- Fugl Meyer Assessment score between 9 to 84
- difficult to understand experimental tasks because of extremely severe cognitive impairment
- history of psychiatric disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dual Stimulation 1 hand motor task i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. Dual Stimulation 1 PMC stimulation i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. Single stimulation hand motor task anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex Dual Stimulation 1 M1 stimulation i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. Dual Stimulation 2 hand motor task i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. Dual Stimulation 2 aIPS stimulation i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. Dual Stimulation 2 M1 stimulation i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. Single stimulation M1 stimulation anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex
- Primary Outcome Measures
Name Time Method Changes in motor evoked potentia Baseline and after intervention (approximately 2 weeks) measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle.
- Secondary Outcome Measures
Name Time Method changes in grip and tip pinch strength test Baseline and after intervention (approximately 2 weeks) measure the hand strength (grip and tip pinch)
Changes in brain activation of resting-state functional MRI Baseline and after intervention (approximately 2 weeks) Neuroplasticity measure
changes in nine hole peg test Baseline and after intervention (approximately 2 weeks) Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses.
Changes of Cortical activation Baseline and after intervention (approximately 2 weeks) Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany)
changes in box and block test Baseline and after intervention (approximately 2 weeks) box and block test measures unilateral gross manual dexterity
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of