Dual Site-Dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Healthy Subjects

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: IFG stimulation; Device: DLPFC stimulation; Device: Sham stimulation

• Registration Number: NCT03486808
• Lead Sponsor: Samsung Medical Center

Brief Summary

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in healthy. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on left inferior frontal cortex, ii) anodal stimulation on left dorsolateral prefrontal cortex. 2) IFG stimulation: anodal stimulation on left inferior frontal cortex; 3) DLPFC stimulation: anodal stimulation on left dorsolateral prefrontal cortex area. 4) sham stimulation

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2018-02-28
• Status Verified: 2018-03
• Study First Submitted: 2018-03-22
• Study First Submitted QC: 2018-04-01
• Study First Posted: 2018-04-03
• Primary Completion: 2018-05-22
• Study Completion: 2018-05-22
• Last Update Submitted: 2019-09-19
• Last Update Posted: 2019-09-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• healthy subjects with age over 19 years old

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Exclusion Criteria

• history of disorders involving central nervous system
• patients with severe medical or psychiatric disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dual stimulation	IFG stimulation	i) anodal stimulation of left inferior frontal cortex ii) anodal stimulation on left dorsolateral prefrontal cortex
DLPFC stimulation	DLPFC stimulation	anodal stimulation on left dorsolateral prefrontal cortex
Sham stimulation	Sham stimulation	sham stimulation
Dual stimulation	DLPFC stimulation	i) anodal stimulation of left inferior frontal cortex ii) anodal stimulation on left dorsolateral prefrontal cortex
IFG stimulation	IFG stimulation	anodal stimulation of left inferior frontal cortex

Primary Outcome Measures

Name	Time	Method
Verbal 3 back test	Baseline and after intervention (approximately 30 minutes)	measure working memory
Korean Boston naming test	Baseline and after intervention (approximately 30 minutes)	measures naming ability thorough picture naming test

Secondary Outcome Measures

Name	Time	Method
Korean Color Word Stroop test	Baseline and after intervention (approximately 30 minutes)	measures selective attention and executive function
Controlled Oral Word Association Test	Baseline and after intervention (approximately 30 minutes)	measure verbal fluency

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of