The Study of Mental Activity and Regular Training for the Prevention of Cognitive Decline in at Risk Individuals: The SMART Trial

Not Applicable

Completed

• Conditions: Cognitive Impairment; Neurological - Neurodegenerative diseases

• Registration Number: ACTRN12608000489392
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Age 55 or above with a corrected Mini-Mental State Exam score of 29 or below; willing to have multiple cognitive, physical and imaging assessments over 12 months; has a suitable informant (if available) that is willing and able to answer questions about their past and current condition; understands and agrees to comply with random allocation process; has telephone at home. There will be 3-stage screening, which includes: Telephone screen by RA of participant and informant (if available) for willingness to participate, sedentary status, no exclusionary medical history, and TICS < or equal to 30. This will be followed by In-person screen by neuropsychologist and later on by In-person screen by geriatrician/stress testing (to ascertain unstable or unsuitable medical conditions).

Exclusion Criteria

Diagnosis of dementia, more than 1 stroke or transient ischemic attack (TIA) or major degenerative neurological disease; current psychotic illness diagnosis, current/past alcohol or drug abuse; current or past use of prescribed cognitive enhancing medication such as cholinesterase inhibitor, nootropic agents; no competency in English, or unable to read and write or use computers due to sensory impairment; high participation in mental activity; current participation in planned structured exercise of any kind other than low- intensity walking 1 or more days per week; Activities of daily living (ADL) or instrumental activities of daily living (IADL) impairment due to cognition; non-ambulatory; contraindications to high intensity progressive resistance training (PRT) or maximal exercise testing

Study & Design

• Study Type: Interventional
• Study Design: Not specified