The Study of Mental Activity and Regular Training for the Prevention of Cognitive Decline in at Risk Individuals: The SMART Trial

niversity of Sydney0 sites100 target enrollmentSeptember 30, 2008

Overview

No summary available.

Registry

who.int

Start Date

September 30, 2008

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•Age 55 or above with a corrected Mini\-Mental State Exam score of 29 or below; willing to have multiple cognitive, physical and imaging assessments over 12 months; has a suitable informant (if available) that is willing and able to answer questions about their past and current condition; understands and agrees to comply with random allocation process; has telephone at home. There will be 3\-stage screening, which includes: Telephone screen by RA of participant and informant (if available) for willingness to participate, sedentary status, no exclusionary medical history, and TICS \< or equal to 30\. This will be followed by In\-person screen by neuropsychologist and later on by In\-person screen by geriatrician/stress testing (to ascertain unstable or unsuitable medical conditions).

•Diagnosis of dementia, more than 1 stroke or transient ischemic attack (TIA) or major degenerative neurological disease; current psychotic illness diagnosis, current/past alcohol or drug abuse; current or past use of prescribed cognitive enhancing medication such as cholinesterase inhibitor, nootropic agents; no competency in English, or unable to read and write or use computers due to sensory impairment; high participation in mental activity; current participation in planned structured exercise of any kind other than low\- intensity walking 1 or more days per week; Activities of daily living (ADL) or instrumental activities of daily living (IADL) impairment due to cognition; non\-ambulatory; contraindications to high intensity progressive resistance training (PRT) or maximal exercise testing