The effect of hesperidin administration on endothelial function and gut barrier function - The effect of hesperidin on endothelial function

niversiteit Maastricht0 个研究点目标入组 68 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•Men/women, BMI 25-35 kg/m2, healthy human beings, age 18-70 years, fasting glucose <7.0 mmol/L, Hba1c between 4.4-6.2%

•Type 2 diabetes mellitus; gastroenterological diseases or abdominal surgery; cardiovascular diseases; cancer; liver or kidney malfunction; disease with life expectancy shorter than 5 years; self admitted HIV-positive status; abuse of products such as alcohol (> 20 alcoholic consumptions per week) or drugs; smoking; plans to lose weight or following a hypocaloric diet; weight gain or loss > 3 kg in previous 3 months; use of medication interfering with endpoints (intake of antihypertensive medication, statins, corticosteroids, NSAIDs, ciclosporin A, rifampicin is strictly forbidden); use of antioxidants, minerals and vitamin supplements available in pharmacies, drugstores, food markets, or in alternative medicine; hormone replacement therapy, use of antibiotics in the 90 days prior to the start of study; known pregnancy, lactatation; history of side effects towards intake of flavonoids or citrus fruits; administration of investigational drugs or participating in any scientific intervention study which may interfere with this study ( to be decided by principal investigator) in the 180 days prior to the study; blood donation within 3 months before study period; Failure to comply prohibited intake of hesperidin containing food products during study period and prohibited intake of food products that are able to influence FMD measurements one day prior to test days.

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