effect of hesperidin on depressio
Phase 3
Recruiting
- Conditions
- Major Depressive Disorder.Major depressive disorder, single episode, severe with psychotic features
- Registration Number
- IRCT20090901002394N40
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
Willing to participate
Clinical diagnosis of major depressive disorder; A score =15 in the 17-item Hamilton Depression Rating Scale;
Age 18 – 65 years;
Good health status based on medical history
No dietary supplement use during the previous two months
No antidepressant or steroid use
Absence of benign hormone-sensitive tumors in the ovary, uterus, breast, prostate
Not having thoughts about death and suicide
Not having any mental illness except anxiety
Do not eat citrus more than two units per day
Exclusion Criteria
Pregnancy and lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of cortisol. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of homocysteine. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of tryptophan. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of kynurenine. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.
- Secondary Outcome Measures
Name Time Method Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: Three-day food record.