Incidence and Predictive Risk Factors of Acute Kidney Injury in Pediatric Polytrauma Patients Admitted to Assiut University Trauma Unit: a Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- timing of AKI in pediatric trauma patients admitted to ER
研究概览
简要总结
This study aims to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized pediatric patients and identify the risk, and severity of AKI. The results would aid the emergency physicians in the early identification of those at risk of AKI to establish a resuscitation strategy that aims at preventing AKI
详细描述
Trauma is a leading cause of morbidity and mortality throughout Africa and the leading cause of mortality worldwide for children and young adults (5-29 years of age).
Organ failure, including AKI, is the third leading cause of mortality in trauma patients, after bleeding and brain injuries.
Trauma patients are at risk of AKI caused by renal hypoperfusion (secondary to haemorrhagic shock), rhabdomyolysis, direct renal injury, abdominal compartment syndrome, or the nephrotoxic effects of therapies.
The majority of trauma-based AKI studies worldwide have looked at critically ill adult trauma patients and these report highly variable AKI rates, ranging 1-50%.
Though pediatric trauma studies on AKI are scarce, a California study suggests 13% of pediatric post-traumatic rhabdomyolysis patients experience AKI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The present study will be conducted on pediatric patients with multiple traumas of both genders aged 2yr to 18 yr who have no previous history of kidney disease or chronic illness.
排除标准
- •Patients who are less than 2 years old or more than 18 years old.
- •Direct trauma kidney or localized individual trauma
- •children with preexisting kidney disease
- •children with drug nephrotoxicity
- •children underwent renal transplant
- •children post-cardiac arrest
- •Patients leaving the hospital on the same day or transferred to a different hospital will be excluded from this study.
- •Patients refusing the study will be excluded.
结局指标
主要结局
timing of AKI in pediatric trauma patients admitted to ER
时间窗: baseline
time period between admission and diagnosis of AKI
Incidence of AKI in Pediatric Trauma Patients Admitted to ER
时间窗: baseline
Describing the true incidence of AKI in pediatric trauma patients who are admitted to ER. a) Identification of AKI according to the KDIGO guidelines as follows: I. Increase in serum creatinine by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours, or II. Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior seven days, or III. Urine volume \<0.5 mL/kg/hour for six hours
次要结局
- mortality outcomes of AKI in pediatric trauma patients(Baseline)
- Risk Identification of AKI in pediatric trauma patients(baseline)
研究者
Doaa Atef Alsayed
resident doctor at emergency medicine department
Assiut University