Mental functioning, brain Tryptophan availability and affect; the role of the immune system

Recruiting

• Conditions: inflammatory bowel disease; irritable bowel syndrome; 10017969; 10027946

• Registration Number: NL-OMON55728
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 68

Inclusion Criteria

- Officially diagnosed gastrointestinal disease: IBD or IBS (no inclusion
criterion for control group)
- Aged between 18- 60 years
- Normal BMI (18.5- 25)
- Willing and able to give written informed consent
- Good understanding of the Dutch language
The control group will be matched as closely as possible with the patient group
on gender and age

Exclusion Criteria

- Indications of acute or chronic disease or psychiatric disorder (other than a
chronic gastrointestinal disease) at study entry
- Symptoms of a cold / fever / the flu at study entry
- Use of medication, apart from contraceptives- especially medications that
affect the dependent variable
- Pregnancy in the last 6 months / breastfeeding
- Known excessive alcohol or drugs use (>15 week)
- Smoking

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter consists of variations in plasma TRP/LNAA ratio<br /><br>(indicator of brain TRP availability). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are pre-post changes in physiological indices of stress<br /><br>and/ or negative affectivity (cortisol), inflammatory reactivity and indicators<br /><br>of subjective stress/ negative affectivity (mood, negative attention bias). </p><br>