Evaluating the Efficacy of Crocin on Movement Disorders and Neuronal Oxidative Stress of Parkinson's Disease
Phase 3
Recruiting
- Conditions
- Parkinson's disease.Parkinson's disease
- Registration Number
- IRCT20170608034390N12
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
Idiopathic Parkinson's patients
Age 30 to 80 years
No change in diet, medication and supplements during 8 weeks
They declare their agreement to participate in the clinical trial through a written consent form
Exclusion Criteria
Patients with a history of saffron allergy
Patients with severe episodes of wearing off
Consumers of saffron more than 1 gram per day
Taking warfarin, monoamine oxidase inhibitors
Pregnant and lactating patients
Liver disease
Occurrence of urticaria complications; skin itching; Nausea and vomiting and dizziness
Patients with severe Hoehn and Yahr stage 5 Parkinson's disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method nified Parkinson's Disease Rating Scale (UPDRS). Timepoint: At the beginning and eight weeks after the start of the study. Method of measurement: Unified Parkinson's Disease Rating Scale (UPDRS) Questionnaire.
- Secondary Outcome Measures
Name Time Method Malondialdehyde reduction in blood (oxidative stress biomarker). Timepoint: The beginning of the study and the end of the study. Method of measurement: Spectrophotometry.