Blood-Brain Barrier function: The key to successful cognitive aging?

Completed

Conditions: age-related decline in mental ability.
Blood-Brain Barrier leakage
Cognitive aging
Blood-Brain Barrier permeability
10009841
10001474
10047079

Registration Number: NL-OMON47086

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 61

Inclusion Criteria

- Informed consent before participation
- Participation in 12-year follow-up of the MAastricht Aging Study
- Mini-Mental State Examination score >= 25
- Disability Assessment for Dementia score > 90%

Exclusion Criteria

- Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
- Contraindications for the gadolinium-containing contrast agent (renal failure) as determined by the estimated Glomerular Filtration Rate < 30 mL/min
- Diagnosis of dementia, prodromal dementia or Mild Cognitive Impairment and in case of doubt prof. dr. Frans R.J. Verhey will decide if the participant may be included
- Diagnosis of other psychiatric or neurological disorders (major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 months); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's Disease; Multiple Sclerosis; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Menière's Disease; brain infections)
- Structural brain abnormalities
- Cognitive impairment due to alcohol/drug abuse or abuse of other substances

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Episodic memory: Verbal Learning Test, delayed recall<br /><br>- Hippocampal volume<br /><br>- Blood-Brain Barrier leakage</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other measures of cognitive performance ( for post-hoc analyses):<br /><br>- Learning: Verbal Learning Test, immediate recall<br /><br>- Basic processing speed: Letter-Digit Substitution Test<br /><br>- Complex information processing: Stroop Color-Word Test<br /><br>- Global cognition: Mini-Mental State Examination<br /><br>Other measures of radiologically visible brain tissue abnormalities (for<br /><br>post-hoc analyses):<br /><br>- Cortical atrophy<br /><br>- White Matter Hyperintensities<br /><br>- Small cortical infarcts<br /><br>- Lacunes<br /><br>- Microbleeds<br /><br>- Enlarged perivascular spaces<br /><br>- White matter integrity</p><br>