Acute coagulopathy and inflammation of trauma

Completed

• Conditions: clotting disorder; coagulopathy; 10064477; 10022114; 10038716

• Registration Number: NL-OMON39604
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 500

Inclusion Criteria

Trauma patients for whom a full trauma team activation is given

Exclusion Criteria

* Age <18
* Patients transferred from other hospitals
* Patients presenting more than 120 minutes after time of injury
* Patients who have received more than 2000 mL of intravenous fluids prior to emergency department arrival
* Patients with burns >5% of their body surface area
* Patients taking anticoagulant medication other than aspirin (<650mg/day)
* Patients with a known bleeding diathesis
* Patients with moderate to severe liver disease (Child's classification B or C)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint:<br /><br>28 day mortality</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints:<br /><br>Blood transfusion requirement in first 24 hours, length of hospital stay, ICU<br /><br>stay, 28-day ventilator free days, occurrence of acute lung injury (ALI), acute<br /><br>respiratory distress syndrome (ARDS), acute kidney injury (AKI) and multiple<br /><br>organ failure (MOF)</p><br>