Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy
- Conditions
- Thoracic Surgery, Video-AssistedPain, Postoperative
- Interventions
- Registration Number
- NCT03648008
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Brief Summary
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Multimodal analgesia combines several agents and/or techniques to function on diverse nociceptive mechanisms to enhance pain relief and lessen side effect. Hydromorphone is a hydrogenated ketone of morphine and approximately 5-10 times more potent. There lacks about efficacy and efficiency of hydromorphone in electrical pump for patient controlled intravenous analgesic (PCIA).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 171
- 70≥ Age ≥18
- Selective operation lung section with video-assisted thoracic surgery (VATS)
- III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
- Patients informed and agreed to join the study
- Abnormal function of liver and kidney
- Allergic- dependence history of alcohol, opioids and Local anesthetics
- No noncompliance
- Mental disease history，language communication disorder，cicatricial diathesis
- Underweight or overweight（BMI<18 or >30)
- Patients not suitable for clinical subjects for other reasons
- Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24 hours before the operation.
- History of previous abnormal anaesthesia
- Women during pregnancy or lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group M Morphine Drug: Morphine Background: No Bolus infusion: 0.015 mg\*kg-1 Group NBH Hydromorphone Drug: Hydromorphone Background: No Bolus infusion: 0.002 mg\*kg-1 Group BH Hydromorphone Drug: Hydromorphone Background: 0.002 mg\*kg-1\*h-1 Bolus infusion: 0.002 mg\*kg-1
- Primary Outcome Measures
Name Time Method Rest pain assessment at 8 a.m. at first day after surgery 8 a.m. at first day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 a.m. at first day after surgery 8 a.m. at first day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 a.m. at second day after surgery 8 a.m. at second day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 p.m. at third day after surgery 8 p.m. at third day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 0.5 hour after tracheal extubation 0.5 hour after tracheal extubation Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 p.m. at second day after surgery 8 p.m. at second day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 a.m. at third day after surgery 8 a.m. at third day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 p.m. surgery day 8 p.m. at surgery day Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 p.m. surgery day 8 p.m. at surgery day Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 a.m. at second day after surgery 8 a.m. at second day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 p.m. at second day after surgery 8 p.m. at second day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 p.m. at third day after surgery 8 p.m. at third day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 p.m. at first day after surgery 8 p.m. at first day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Activity pain assessment at 8 p.m. at first day after surgery 8 p.m. at first day after surgery Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Rest pain assessment at 8 a.m. at third day after surgery 8 a.m. at third day after surgery Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
- Secondary Outcome Measures
Name Time Method Total Analgesia usage 8 p.m. at third day after surgery Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Ratio of Nausea 8 p.m. at third day after surgery Record whether patients experience nausea
Ratio of Vomiting 8 p.m. at third day after surgery Record whether patients experience vomiting and how many times do they experience
Total Antiemetic usage 8 p.m. at third day after surgery Sum up any antiemetic from last time point
Trial Locations
- Locations (1)
The second affiliated hospital of Zhejiang University
🇨🇳Hangzhou, Zhejiang, China