Therapeutic effect of oral NAC on Sinusitis
Phase 3
- Conditions
- subacute Sinusitis.
- Registration Number
- IRCT138806112406N1
- Lead Sponsor
- Research managment center of Bushehr University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Presence of subacute sinusitis according to signs and symptoms 3 weeks to 3 months and signs of sinusitis in CT scan
Exclusion criteria: Presence of allergic rhinitis, asthma, pregnancy, diabetes mellitus, transplantation, CRF, chronic alcoholism, severe malnutrition, AIDS, Down syndrome, history of migraine, HTN, BPH, consumption of antidepressants, Methyl dopa, Propranolol, or Warfarin, history of kidney stone, or liver disease, more than 60 years old age, drivers, or pilots
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Culture of nasal secretion. Timepoint: 1 month after competement of treatment. Method of measurement: microbiological culture.;Signs and symptoms of disease. Timepoint: 1 day after completement of treatment. Method of measurement: face to face completement of Snot 20 questionnaire by a physician.;Involvement of paranasal sinuses. Timepoint: 1 month after competement of treatment. Method of measurement: CT scan, cure rate of sinusitis according to Lund-Mackay score.
- Secondary Outcome Measures
Name Time Method Clinical improvement. Timepoint: 1 day and one month after copletement of treatment. Method of measurement: snot20 questionaire.;Radiological improvement in paranasal CT scan. Timepoint: 1 month after completment of treatment. Method of measurement: Lund-Mackey score.