Natural History of Atherosclerosis

Completed

• Conditions: Atherosclerosis

• Registration Number: NCT00918541
• Lead Sponsor: University of Zurich

Brief Summary

20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2008-11-19
• Study First Submitted QC: 2009-06-10
• Study First Posted: 2009-06-11
• Primary Completion: 2010-03
• Study Completion: 2010-03
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-22
• Last Update Posted: 2011-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• stable carotid artery disease not requiring revascularization
• asymptomatic carotid artery stenosis < 80% or symptomatic patients with stenosis < 60 %
• prophylactic therapy with aspirin (> 100mg/day, statin, blood pressure therapy if indicated (goal < 130/80 mmHg))
• informed consent

Exclusion Criteria

• non atherosclerotic occlusive disease (Bürgers disease)
• uncontrolled BP (DBP > 110 mmHg and/or SBP > 200 mmHg)
• hemorrhagic disease or platelet count < 100'000 mm^3
• Known active liver disease (elevations of GPT GOT or increased ammonia)
• impaired renal function (crea > 180 mmol/l)
• pregnancy
• severe claustrophobic reactions
• short - term life - threatening pathology
• physically unable to participate in the study
• compliance not guaranteed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progression of atherosclerotic plaque	12 months

Trial Locations

Locations (3)

Ospedale San Giovanni; 🇨🇭 Bellinzona, Switzerland

Ospedale San Giovanni Bellinzona; 🇨🇭 Bellinzona, Switzerland

Cardiovascular Center Cardiology University Hospital Zürich; 🇨🇭 Zürich, Switzerland