Local Ischemic Postconditioning in Acute Ischemic Stroke

Not Applicable

Not yet recruiting

• Conditions: Acute Ischemic Stroke; Mechanical Thrombectomy; Ischemic Postconditioning; Brain Edema; Neuroprotection

• Registration Number: NCT06526429
• Lead Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-7-24
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Inclusion Criteria:<br><br> - Age = 18 years old<br><br> - Presenting with symptoms and signs consistent with acute anterior circulation<br> ischemic stroke<br><br> - Pre-stroke modified Rankin Score 0-1<br><br> - Baseline National Institute of Health Stroke Scale (NIHSS) score=6<br><br> - Endovascular treatment can be initiated (femoral puncture) within 24 hours from<br> stroke onset (stroke onset time is defined as last known well time)<br><br> - Occlusion of the intracranial internal carotid artery, or the middle cerebral artery<br> (MCA) (M1 or M2) and is the culprit artery<br><br> - Ischemic core volume is < 70 ml, mismatch ratio is >1.8 and mismatch volume is >15<br> ml as determined by CT perfusion imaging<br><br> - Embolism verified as the etiology of occluded artery and modified Thrombolysis in<br> Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy.<br><br> - Time from CT perfusion to reperfusion < 2 hours<br><br> - Informed consent signed<br><br>Exclusion Criteria:<br><br> - Stenosis of the proximal middle cerebral artery, internal carotid artery, or common<br> carotid artery (=50%) of the culprit artery<br><br> - Evidence of internal carotid artery lesion that precludes the access and application<br> of balloon guide catheter<br><br> - Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or<br> an MCA and a basilar artery occlusion)<br><br> - Pre ischemic stroke within past 3 months<br><br> - The expected survival time is less than 6 months, could not be followed at 90 days<br> (such as patient with malignant tumor)<br><br> - Currently pregnant, mental disease, advanced hepatic and renal insufficiency, severe<br> heart failure<br><br> - Participation in other interventional randomized clinical trials that may confound<br> the outcome assessment of the trial<br><br> - Other circumstances that the investigator considers inappropriate for this trial

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of Treatment-Emergent Adverse Events