Influence of effective noninvasive positive pressure ventilation on biomarkers in stable hypercapnic COPD patients
Not Applicable
- Conditions
- J44.9Chronic obstructive pulmonary disease, unspecified
- Registration Number
- DRKS00007644
- Lead Sponsor
- Firma Resmed
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
COPD patients in stadium GOLD iV with hypercapnia (PaCO2 > 50 mmHg)
Stable state of disease (pH >7,33)
Exclusion Criteria
•Severe Obesity (BMI > 35 kg/m2)
•Restrictive lung disease (total lung capacity <80%)
•Acute infections including acute pulmonary exacerbation
•Chronic inflammatory diseases other than COPD or atherosclerosis that could be potential confounders (e.g. rheumatic disease, collagenoses, etc.)
•Malignant disease
•Anti-inflammatory or immunosuppressive drugs other than statins, aspirin or clopidogrel
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method octurnal PaCO2 measured at 4 a.m. before and after initiation of noninvasive ventilation
- Secondary Outcome Measures
Name Time Method