Tobacco Approach Avoidance Training for Adolescent Smokers-1

Phase 2

Completed

• Conditions: Tobacco Use Disorder
• Interventions: Behavioral: AAT experiment

• Registration Number: NCT01625767
• Lead Sponsor: Yale University

Brief Summary

This is a two part study. Study 1 will compare Approach Avoidance Training (AAT) responses in smokers and nonsmokers in order to confirm that adolescent smokers experience cognitive bias towards tobacco-related stimuli.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Study First Submitted: 2012-06-19
• Study First Submitted QC: 2012-06-20
• Study First Posted: 2012-06-21
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-19
• Last Update Posted: 2013-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Between ages 13-18 years
• Able to read and write in English.
• Smokers: Smoking 5 or more cigarettes daily for at least 6 months; Baseline urine cotinine levels > 500 ng/ml
• Nonsmokers: Never smokers; Baseline urine cotinine levels < 50 ng/ml

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Exclusion Criteria

• Current criteria for dependence on another psychoactive substance
• Current diagnosis of psychosis, major depression or panic disorder
• Regular use of any psychoactive drugs including anxiolytics and antidepressants unless the medication has been taken consistently for 2 months, is currently being monitored by a physician, and the condition for which the medication is taken is considered to be stable
• Pregnant or lactating girls, based on self report.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Approach Avoidance Task experiment	AAT experiment	Approach Avoidance Task experiment

Primary Outcome Measures

Name	Time	Method
automatic approach tendencies towards smoking-related stimuli	at end of AAT at Day 29	For all AAT comparisons, the investigators will compare median scores (to minimize influence of outliers) for cigarette approach and cigarette avoid RTs. The difference between these values gives the smoking AAT-scores, which the investigators expect to not differ from zero in the non-smokers (or to show mild avoidance), while it is expected that smokers will be faster to approach than to avoid cigarettes. ANOVA models will be used to compare scores in smokers vs. nonsmokers. Regression analyses will be used to explore the relationships between impulsivity-related measures and AAT responses.

Trial Locations

Locations (1)

Yale University, School of Medicine, Dpeartment of Psychiatry; 🇺🇸 New Haven, Connecticut, United States