Bile acid sequestrants in non-healing Barrett's esophagus after endoscopic therapy - a retrospective evaluatio

Recruiting

• Conditions: C15; Malignant neoplasm of oesophagus

• Registration Number: DRKS00023947
• Lead Sponsor: Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients who presented to our center between April 2014 and March 2020 and met the following criteria:

- Coded principal diagnosis adenocarcinoma of the gatroesophageal junction (AEG), coded under ICD codes C15.9 and C16.9
- Histological confirmation of the findings
- Documented endoscopically insufficient squamous reepithelialization.
- Presence of endoscopic control examination in the center

Exclusion Criteria

- Squamous cell carcinoma
- Wound healing disorder after oesophageal resection

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Improvement of endoscopic healing under applied therapy regimens.<br>- Achieving complete squamous cell healing.

Secondary Outcome Measures

Name	Time	Method
- Influence of patient characteristics.<br>- Influence of extent of initial Barrett's esophagus and maximal dys- or neoplasia.<br>- Influence of endoscopic therapy.<br>- Influence of relevant concomitant medication.<br>- Occurrence of dys- or neoplasia in Neobarrett's.