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Clinical Trials/ChiCTR2000040094
ChiCTR2000040094Active, not recruitingEarly Phase 1

电针与 TMS 配对联合刺激对大脑运动皮层 LTP、LTD 效应的研究

2019 年广东省中医院院内专项1 site in 1 country70 target enrollmentStarted: November 18, 2020Last updated:
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Trial Snapshot

Phase
Early Phase 1
Status
Active, not recruiting
Sponsor
Enrollment
70
Locations
1
Primary Endpoint
运动诱发电位
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

比较电针与 TMS 配对联合刺激模式与传统 PAS 模式对脑可塑性的影响

Study Design

Study Type
干预性研究
Primary Purpose
随机交叉对照
Masking
未说明

Eligibility Criteria

Ages
18 to 50 (—)
Sex
All

Inclusion Criteria

  • •（1）健康受试者，年龄在 18~50 岁；
  • •（2）右利手，性别不限；
  • •（3）既往无神经、精神、运动系统疾患者；
  • •（4）近 3 个月内未接受过任何外周刺激（如针灸、外周电刺激等）及中枢刺激（如 rTMS、tDCS 等）；
  • •（5）愿意接受电针，无晕针史；
  • •（6）自愿参加本研究并签署知情同意书者。

Exclusion Criteria

  • •（1）有精神系统疾患者，如：精神分裂、焦虑症、人格障碍等；
  • •（2）有神经系统疾患者，如：脑外伤、颅后窝疾病、痉挛症、三叉神经痛、Jackson 癫痫、面神经麻痹后痉挛、眼睑痉挛、认知障碍、言语障碍及痴呆等；
  • •（3）有严重高血压、糖尿病、恶性肿瘤等病史；有严重的心、肝、肾等脏器的疾患；
  • •（4）体内有金属残留物者（包括义齿、起搏器、神经刺激器、医疗泵等）；
  • •（5）对 TMS 畏惧以及其它原因不能进行 TMS 刺激者；
  • •（6）畏惧针刺或出现针刺不良反应者；
  • •（7）妊娠或哺乳期妇女

Arms & Interventions

1

电针内关+TMS，15min

2

正中神经电刺激+TMS，15min

3

电针内关，15min

4

TMS，15min

Outcomes

Primary Outcomes

运动诱发电位

Secondary Outcomes

  • 阈值
  • 皮层静息期

Investigators

Sponsor
2019 年广东省中医院院内专项

Study Sites (1)

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电针与TMS配对联合刺激对大脑运动皮层LTP、LTD效应的研究 | Clinical Trial