Efficacy of periarticular tranexamic acid administration in elderly individuals with femoral neck fracture undergoing hemiarthroplasty: A randomized controlled trial

Phase 2

Completed

• Conditions: Efficacy in blood loss reducing of peri-articular TXA injection in patients who have undergone hemiarthroplasty.; Tranexamic acid, Periarticular injection, Hip hemiarthroplasty, Blood loss

• Registration Number: TCTR202102090010
• Lead Sponsor: Faculty of Medicine Vajira Hospital, Navamindradhiraj University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-09
• Study Completion: 2023-04-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Patient with femur neck fracture who undergoing bipolar hemiarthroplasty
2. Age 40 - 90 years old
3. No history of surgical fixation of the affected femur neck
4. Low energy trauma

Exclusion Criteria

1. Preoperative hemoglobin < 10 g/dL or a platelet count < 140,000 /uL3
2. Renal Insufficiency ( Defined by creatinine clearance < 30 mL/min )
3. Previous unprovoked and/or recurrent deep venous thrombosis or pulmonary embolism
4. Recent myocardial infarction , cerebrovascular event , or provoked deep venous thrombosis or pulmonary embolism within 30 days , Coronary stent placement with in 6 month
5. On oral contraceptives pill or drug with drug-interaction ie : Thrombin , Hemocoagulase , Batroxobin , Eptacog-alfa
6. On Anti-coagulants
7. Hypercoagulable state
8. Intolerance or allergy to any drug prescribed in the study
9. Refusal to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of patients received transfusion (%) 3 days postoperative Percentrage,Number of blood units transfused 3 days postoperative Units,Calculated blood loss 3 days postoperative Calculation from formula ,Intraoperative blood loss Postoperative Millimetre,Hemoglobin drop post-op day 3 3 days postoperative g/dL,Hemoglobin drop post-op day 1 1 day postoperative Laboratory result

Secondary Outcome Measures

Name	Time	Method
Tranexamic acid-related adverse effects 3 days postoperative Postoperative Recording,Postoperative wound complications 3 days postoperative Postoperative Recording