What is the effect of an antibody directed against IL-5 (Mepolizumab) in the inflammatory reaction in asthmatic patients
- Conditions
- Eosinophilic asthma, action of mepolizumab on lung inflammation.
- Registration Number
- NL-OMON26875
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Age>18 and younger than 70 years
Diagnosis of eosinophil asthma despite use of corticosteroids
suitable for sputum induction
Exclusion Criteria
Any infection (e.g. HIV, hepatitis, STD's)
Insulin dependent diabetes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in kinetics of eosinophils in the sputum
- Secondary Outcome Measures
Name Time Method change in kinetics of eosinophils in the sputum<br /><br>change in systemic cytokines <br /><br>change in sputum markers for presence of eosinohils<br />