ocal microvascular reactivity to Acetylcholine in patients with essential hypertension: possible interactions with the local renin-angiotensin system.

Completed

• Conditions: high blood pressure; Hypertension; 10057166

• Registration Number: NL-OMON31352
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Inclusion criteria hypertensive patients:
- Age:18-65 year
- Caucasian
- Untreated blood pressure > 140/90 mmHg
- In consultation with the internist, anti-hypertensive medication will be
stopped 3 weeks prior to the start of the experiment. ;Inclusion criteria normotensive volunteers:
- Age:18-65 year
- Caucasian
- Blood pressure <140/90 mmHg

Exclusion Criteria

- Secondary hypertension
- Diabetes mellitus according to the criteria of the ADA
- Kidney failure: serum creatinine > 150 µmol/l
- Unable to stop blood pressure lowering medication during a period of
3 weeks
- Use of blood cholesterol lowering medication
- (Hypertensive) retinopathy, glaucoma or conjunctival disease
- Connective tissue disease
- Contact lenses

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in vascular diameters of bulbar conjunctiva, and changes in skin<br /><br>laser-Doppler flux. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>/</p><br>