Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring

Not Applicable

• Conditions: Thyroid Cancer; Neck Cancer; Recurrent Laryngeal Nerve Injuries; Accessory Nerve Injuries; EMG: Repetitive Nerve Stimulation Abnormality
• Interventions: Drug: Lidocaine

• Registration Number: NCT03530033
• Lead Sponsor: Bo Wang,MD

Brief Summary

In recent years, the application of intraoperative recurrent laryngeal nerve monitoring in thyroid surgery has greatly reduced the complications of recurrent laryngeal nerve injury. The use of intraoperative neurological monitoring requires the reduction of the dose of neuromuscular blockade, which often leads to muscle tremors during the application of electrical energy, which affects the fine separation around the muscles. This study explored the effect of local application of lidocaine on reducing muscle tremor during surgery and its optimal dose.

Detailed Description

According to the random number method, eligible patients were randomly divided into 2 groups. Group A was the conventional surgery group, and Group B was the lidocaine group. The operative time for the separation of the sternocleidomastoid muscle from the two groups of patients was analyzed, as well as the length of time for the search for the accessory nerve and the effect of intraoperative nerve monitoring on the EMG signal.

Study Timeline

• Study Start: 2018-05-01
• Study First Submitted: 2018-05-08
• Study First Submitted QC: 2018-05-17
• Study First Posted: 2018-05-21
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-17
• Last Update Posted: 2018-09-18
• Primary Completion: 2018-10-31
• Study Completion: 2018-10-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Thyroid papillary carcinoma
• Lateral cervical lymph node metastasis
• The diameter of the metastatic lymph nodes is less than 3cm
• Without internal jugular vein invasion

Exclusion Criteria

• Lidocaine allergy sufferers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lidocaine group	Lidocaine	Anesthesia induction was performed according to conventional nerve monitoring neuromuscular blockade doses and lateral neck dissection was performed. When local muscle tremors occur, lidocaine is injected locally to eliminate muscle tremors.

Primary Outcome Measures

Name	Time	Method
Anatomical time of accessory nerve	At the end of surgery	Anatomical time of accessory nerve
Number of nerve signal loss cases	At the end of surgery	Number of nerve signal loss cases
dose of muscle relaxant drugs	At the end of surgery	dose of muscle relaxant drugs
The satisfaction of sternocleidomastoid muscle separation	At the end of surgery	The visual score was 5 points for the most satisfaction and 0 points for the most dissatisfied.
dose of lidocaine	At the end of surgery	dose of lidocaine

Trial Locations

Locations (1)

Fujian Medical University Union Hospital; 🇨🇳 FuZhou, Fujian, China