Effect of Intraligmentary Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block Versus Buccal Infiltratation in Lower First Molars With Irreversible Pulpitis and Apical Periodontits: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 81
- 主要终点
- Intraoperative pain
研究概览
简要总结
Using intraligmentary dexamethasone to reduce the pain intensity during and after root canal preparation
详细描述
Aim :asseing the effect of intraligmentary dexamethasone on anesthetic efficacy of inferior alveolar nerve block and buccal infiltratation in lower first molar with irreversible pulpitis and apical periodontits, dexamethasone has antiinflammatory effect so it will improve the efficacy of anathesia and reduce postoperative by inhibition the production of phosopholipase and reduction of prostaglandins synthesis
Methods: diagnose the case clinically and readiographically Patients will divide into 3 groups First group will be given inferior alveolar nerve block 4%articaine Hcl1:100 epinephrine Second group will be given inferior alveolar nerve block 4%articaine with intraligmentary dexamethasone Third group will be given buccal infiltratation 4%articaine with intraligmentary dexamethasone After anathesia ,make access cavity and reduce the occulsa surface and make it out of occulsion .
Working length determination will be done by apex locator and confirm it by x ray .
Mechanical preparation will be done by FANTA files and apply EDTA on files Irrigate the canal by Naocl 2.5٪ Complete the root canal preparation through single visit. Obturate the canal by single cone technique and bioceramic sealer. During procedures , record pain intensity on HP visual scale Follow up the patient after 6,12,24 and 48 hours Describe Ibuprofen 200mg in case of sever pain Conclusion : it's predictable that the intraligmentary dexamethasone will reduce the pain during and after root canal procedures
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 20-45 years old.
- •Systemically healthy patient (ASA I or II).
- •Lower first molar with:
- •Preoperative sharp pain.
- •Slight widening in the periodontal ligament (PDL).
- •Vital response of pulp tissue to cold pulp tester (ethyl chloride spray).
排除标准
- •Patients allergic to anesthetics, or dexamethasone (other corticosteroids).
- •Pregnant or nursing females.
- •Patients having significant systemic disorder (ASA III or IV).
- •Hemostatic disorders or anti-coagulant therapy during the last month.
- •Consumption of opioid or non-opioid analgesics or corticosteroids during the last 12 h before treatment.
- •Retreatment cases.
结局指标
主要结局
Intraoperative pain
时间窗: During procedure
Efficacy of buccal infiltration anesthesia and inferior alveolar nerve block measured during procedures of root canal treatment using numerical rating scale.It is a line numbered from 0-10 , where pain levels are categorized as follows: 0= no pain, 1-3 = mild pain, 4-6= moderate pain, 7-10= severe pain, "10" being the most intense pain conceivable.And instruct patient to raise his hand if he feels pain to reasse if he needs supplementary anathesia
次要结局
- Number of needed analgesic tablets in case of intolerable pain(After procedure until 48hour)
- Post-operative pain(After procedure until 48hour)
研究者
Wafaa Rezk Elshafaey
Prof.Dr. Angie Galal Ghoneim
Cairo University