Preventive effect of minocycline on postoperative cognitive dysfunction in Japanese elderly patients: A randomized, double-blind, placebo-controlled trial
Not Applicable
- Conditions
- The elderly patient who undergoes total knee arthroplasty(TKA)
- Registration Number
- JPRN-UMIN000014620
- Lead Sponsor
- Gunma University Hospital, Department of Anesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
1)The patient with the mental disease 2)The patient with the drug dependency or alcoholism 3)The patient with cardiac disease 4)The patient with hepatic disease 5)The patient with renal disease 6)The patient with allergy to tetracycline including minocycline 7)The patient taking calcium, magnesium, aluminum, lantern, iron medicine, anticoagulant,sulfonylurea-based hypoglycemic drug, methotrexate, porfimer sodium, digoxin,oral contraceptive, vitamine A 8)The patient to whom a doctor judged inappropriate for participating in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We are going to evaluate the cognitive function 1 week and 3 months after the surgery to test whether minocycline can decrease the incidence of POCD.
- Secondary Outcome Measures
Name Time Method We are going to compare the incident rate of delirium between minocycline and placebo group within 1 week after surgery.