Failing maternal-fetal tolerance in SLE: finding the molecular mechanisms behind pregnancy complications

Recruiting

• Conditions: pregnancy complications in lupus; pregnancy complications in SLE (Systemic Lupus Erythematosus); 10003816; 10010273

• Registration Number: NL-OMON50311
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 88

Inclusion Criteria

Age 18 years or older
Antenatal care and delivery in the Department of Obstetrics and Gynecology of
Amsterdam UMC
Patients diagnosed with SLE
Signed informed consent

Exclusion Criteria

Persons unable to give informed consent
Healthy controls: diagnosis with systemic inflammatory disease, or malignant
disease.
Multifetal pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the differences in the profile and function of<br /><br>stromal and immune cells from the placenta of healthy pregnancies,<br /><br>uncomplicated SLE pregnancies and complicated SLE pregnancies.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A secondary study parameter is the establishment of an in vitro organoid-based<br /><br>model for the maternal-fetal interface. </p><br>