Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

Not Applicable

Completed

• Conditions: Cognition
• Interventions: Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air

• Registration Number: NCT06555484
• Lead Sponsor: Inogen Inc.

Brief Summary

Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.

Detailed Description

Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).

Study Timeline

• Study Start: 2024-05-28
• Study First Submitted: 2024-07-27
• Study First Submitted QC: 2024-08-12
• Study First Posted: 2024-08-15
• Primary Completion: 2024-10-31
• Study Completion: 2024-10-31
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-30
• Last Update Posted: 2025-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Adult (aged 22+)

Exclusion Criteria

• Patients who self-report diagnosis of respiratory-related conditions will be excluded.
• Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Air First	Cross Over Assignment Supplemental Oxygen and Supplemental Air	All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.
Oxygen First	Cross Over Assignment Supplemental Oxygen and Supplemental Air	All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.

Primary Outcome Measures

Name	Time	Method
2 back Memory test performance	At baseline and 5 mins post-intervention exposure	# correct on 2-back test
Memory test performance	At baseline and 5 mins post-intervention exposure	New Medical Icons Spatial Test

Trial Locations

Locations (1)

Two Liberty Place; 🇺🇸 Philadelphia, Pennsylvania, United States